Ribonucleotide reductase inhibitors as anti-herpes agents.
نویسندگان
چکیده
Ribonucleotide reductases (RNRs) supply the 2'-deoxyribonucleotide building blocks for DNA synthesis in mammalian cells and for herpes viruses. The viral-encoded RNRs have unique protein sequences that differ from mammalian enzyme primary structures. Selective inhibition of a viral RNR might provide an approach to new anti-herpes agents with minimal effects on the mammalian host RNRs. This review summarizes efforts to develop anti-herpes agents that selectively target viral-encoded RNRs.
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ورودعنوان ژورنال:
- Antiviral research
دوره 71 2-3 شماره
صفحات -
تاریخ انتشار 2006